Scientists trying to understand what role sex plays
Four scientists: Professors Andrew L. Webb, Brayden G. Schindell, Jason Kindrachuk, and Jia B. Kangbai have noted one area in the spread of the Ebola hemorrhagic fever that requires further study. It is the Ebola virus’ persistence in the reproductive systems of otherwise healthy survivors. They say understanding how Ebola disease outbreaks are exacerbated by sexual transmission is important to stop new chains of transmission and to prevent the disease from spreading to new geographic regions.
The current Ebola disease outbreak in the Democratic Republic of the Congo (DRC) is the second largest in history. It has been raging for over a year with no indication that it is nearing an end. Many of the issues that prevent effective containment of Ebola disease outbreaks have been discussed. These include porous borders, community mistrust of health workers, and the spread of misinformation.
But one area that requires further study is Ebola virus’ persistence in the reproductive systems of otherwise healthy survivors. Understanding how Ebola disease outbreaks are exacerbated by sexual transmission is important to stop new chains of transmission and to prevent the disease from spreading to new geographic regions.
Multiple reports strongly suggest that re-emergence of Ebola disease is linked to persistent infections and sexual transmission from survivors. What this means is that people who have survived infection by Ebola virus – and who no longer show any symptoms of the disease – can continue to carry the virus and pass on the infection months after they have recovered.
Our research group recently reviewed the current understanding of rates and mechanisms of Ebola virus persistence in male disease survivors. We are using this information to fill in gaps about how persistence relates to sexual transmission of the virus.
In addition, we are combining molecular investigations with insights from survivors to better equip future outbreak response efforts. We also hope the work will help address long-term health issues faced by Ebola disease survivors.
The role of the reproductive system
Nearly everything known about Ebola virus persistence in the reproductive system has resulted from testing semen of West African Ebola disease survivors.
It has been established that the Ebola virus can be detected in semen long after it is cleared from other organs and tissues. For example, a recent study showed that the virus could be detected in 50% of male survivors 115 days after recovery and may linger for up to three years.
The virus has also been detected in semen at concentrations greatly exceeding that found in the blood at peak infection. The data suggests that this occurs in the absence of any symptoms of disease. In addition, sexual transmission of Ebola virus from male survivors has been reported up to 18 months following their recovery.
These observations are important to public health. Firstly, long-term persistence of Ebola virus could lead to the initiation of new chains of disease transmission long after outbreaks have ended. Secondly, the presence of high concentrations of virus in the semen in the absence of disease symptoms means that male survivors could carry and transmit the virus without knowing they’re still infected.
But the fact that only semen is being used in these studies presents a problem. This means that the perseverance of the virus is only being traced in males. This means that little is known about persistence of the virus in women. This urgently needs attention because Ebola virus has been detected in female survivors up to 15 months following recovery, and there are recorded cases of female to male transmission.